25-036_SS_MP Bioinformatician - Hereditary Cancer group

REF: 25-036_SS_MP

About the research group

The candidate will have the opportunity to work within the DNA Mismatch Repair team of the Hereditary Cancer Group (https://hereditarycancergroup.com/team/dna-mismatch-repair-laboratory/), by Dr. Gabriel Capellá and Marta Pineda.
The overarching goal of group is to gain insight into the molecular basis of Lynch syndrome (LS) and Constitutional Mismatch Repair Deficiency (CMMRD) to personalize risk assessment to patients and relatives, as well as to individualize management regarding follow-up, treatment and prophylactic measures.
Successful candidates will join a dynamic, young and well-equipped research group with strong interactions and multidisciplinary team including bioinformaticians and wet lab researchers. The group offers a stimulating environment in which collaboration and exchange of ideas, techniques and pipelines is actively encouraged.

About the role

We are seeking a talented and motivated Bioinformatician to join our multidisciplinary team. Our research focuses on LS and CMMRD, two hereditary cancer syndromes caused by constitutional pathogenic variants in genes involved in DNA mismatch repair. LS is associated with an increased risk of colorectal, endometrial (EC), and other cancers. Despite intensive surveillance currently based on invasive and often painful procedures, interval tumors are common. CMMRD is a very rare and devastating syndrome that predisposes to a broad spectrum of tumors in the childhood with brain and hematological neoplasias being the most frequent. We aim to identify and characterize tissue-specific biomarkers in MMRD-associated cancers to improve surveillance and prevention strategies.

The successful candidate will play a key role in the projects developed in our group by contributing to the comprehensive characterization of biological samples from patients and disease models, integrating bioinformatics approaches and in collaboration with senior scientists.

The tasks of the position will encompass:

     - Developing and/or applying Next Generation Sequencing (NGS) pipelines: WES, RNA-seq, methylation arrays, gene panels.

     - Supporting advanced techniques such as scRNA-seq and spatial transcriptomics.

     - Performing post-analysis of -omics data, focusing on the identification of biomarkers and early events in disease progression.
     
     - Refining and automating in-house bioinformatics pipelines.

The selected candidate will work in a highly translational environment, closely collaborating with a multidisciplinary team offering a unique opportunity to contribute to research with clinical relevance while further developing their bioinformatics skills.

Job requirements

Professional experience

• Proven experience in applying NGS pipelines and –omics data analyses (WES, RNAseq, gene panels)
• Professional experience in a similar role or related field

Education and training

•  CFGS related with sciences 

Technical & soft skills

• Proven experience working Linux environment
• Strong programming skills in R

Languages

• Good command of the English language

We will value, but not required

• Proficiency in additional programming languages (e.g. Python).
• Strong knowledge in biostatistics.
• Familiarity with collaborative software platforms like GitHub.
• Experience with high-performance computing or use of clusters
• Experience in the development and use of software containers
• Experience in scRNAseq and/or spatial transcriptomics
• Background in cancer research
• Any participation in research projects, co-authorship in publications and mobility experience will be considered as a valuable contribution.
• High motivation and ability to be involved in a multidisciplinary team.
• High degree of work autonomy.

What do we offer

• No. of positions: 1
• Estimated start date: As soon as possible
• Contract duration: meses
• Estimated annual gross salary: 22.894,74 €
• You will be part of a multicultural team. We have a fun loving and friendly international work environment.
• Flexible working schedule - We know you have a life outside of work and we will work with you to make sure it's kept that way.
• Possibility to work some days in remote -Teleworking
• 26 working days of holiday per year
• System of accumulated hours for employees, from 88 to 104 hours depending on the year (11 to 13 working days), to attend to personal matters.
• Paid leave package
• Benefits of constant training are offered
• We offer and promote diverse and inclusive conditions. Applicants are made free from any discrimination. Specifically IDIBELL works to improve gender equality in all areas with the aim of achieving gender balance, but maintaining the most scrupulous respect to any choice at the level of gender identity. Please express yourself freely, safely and non-binarily, if that's the case.

Deadline: Please submit your application by 31/03/2025

Data protection notice

In compliance with the obligations established in the General Regulation of Data Protection (RGPD), which is the Regulation (EU) 2016/679 of the Parliament and of the Council, of April 27, 2016, and the Organic Law 3/2018, of December 5, Protection of Personal Data and guarantee of digital rights, it is reported that the Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), CIF G58863317, with address Av. Granvia de l'Hospitalet, 199-203, 08908, L'Hospitalet de Llobregat, will process your personal data, as the controller, to apply for the position, maintain communication concerning the status of the candidature, to access the delivered CV; to compare that your data is in accordance with the offers announced by IDIBELL and to verify, where appropriate, that the information provided is accurate. You can find more information in our Privacy Policy at https://idibell.cat/en/privacy-policy-2/, request more information about the data processing carried out and exercise your rights of access, rectification, deletion, opposition, portability, limitation of processing by sending a request at email: dataprotection@idibell.cat. If you consider that you have not obtained satisfaction in exercising your rights, you may submit a claim to Catalan Data Protection Authority.

Our institute

IDIBELL is a research center that integrates the biomedical research of the Bellvitge University Hospital (HUB), the Catalan Institute of Oncology (ICO), and the University of Barcelona in the Bellvitge Campus (UB), and the Viladecans Hospital (HV). The research focuses of IDIBELL are cancer, neuroscience, translational medicine and regenerative medicine. Research, innovation and society are the pivots on which researchers work every day in order to improve the quality of life of citizens.

Observations:

The 'HR Excellence in Research' award represents IDIBELL’s commitment to the implementation of Human Resources policies, which oversee the attracting and development of talent in an open, transparent, and based on personal merit, in alignment with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment Researchers (Charter and Code).

IDIBELL is committed to the principles of the Code of Conduct for the Recruitment of Researchers of the European Commission and the implementation of open, transparent and merit-based recruitment (OTMR).