Auxiliary Support Technician - Cancer Immunotherapy

Ref.: 24-108_SS_RA

About the research group

The Cancer Immunotherapy research group focuses on pioneering anticancer treatments using oncolytic adenoviruses and other innovative immunotherapies. We are currently expanding our research to include a new line of investigation centered on CAR-modified NK and T cells for advanced cellular immunotherapy.

About the role

The ongoing research line focuses on designing new CARs (Chimeric Antigen Receptors) for cancer treatment. This development encompasses the entire process, from in silico CAR design to the generation of viral vectors, modification of effector cells, and validation in both in vitro and in vivo models.

Key responsibilities include:

• Assisting in the generation of lentiviral vectors encoding CAR constructs for producing CAR-NK cell therapy products.
• Supporting the comparative analysis of CAR-NK therapies, evaluating classic CAR constructs against novel proposals through in vitro assays (cytotoxicity, activation via flow cytometry, and cytokine production via ELISA) and in vivo assays (using immunodeficient models with T-cell lymphoma tumors).
• Aiding in the validation of a modular CAR system in CAR-T therapies, including thorough in vitro and in vivo testing.
• Contributing to the development of modular T-cell activation systems based on tumor-specific TCRs.

Job requirements

Professional experience

• Not required

Education and training

• CFGM in Laboratory Technician or a related field

Technical & soft skills

• Knowledge of preclinical cancer models and in vivo studies
• Advanced technical skills in immunological techniques such as cytometry and human T-cell transduction
• Proficiency in molecular biology techniques, including the use of lentiviral vectors, gene cloning, and plasmid amplification
• Hands-on experience with T and NK cell manipulation and CAR evaluation
• Highly organized, self-motivated, and a strong team player

Languages

• Not required

We will value, but not require

• Previous experience in immunology and genetic engineering
• Experience with T cells or NK cells

• Knowledge of molecular biology and flow cytometry
• University degree in Biotechnology or a realted field
• Knowledge of bioinformatics

What do we offer

• No. of positions: 1
• Estimated start date: 16/09/2024
• Contract duration: 3,5 months
• Estimated annual gross salary: 18.000 €
• You will be part of a multicultural team. We have a fun loving and friendly international work environment.
• Flexible working schedule - We know you have a life outside of work and we will work with you to make sure it's kept that way.
• Possibility to work some days in remote - Teleworking
• 26 working days of holiday per year
• System of accumulated hours for employees, from 88 to 104 hours depending on the year (11 to 13 working days), to attend to personal matters.
• Paid leave package
• Benefits of constant training are offered
• We offer and promote diverse and inclusive conditions. Applicants are made free from any discrimination. Specifically IDIBELL works to improve gender equality in all areas with the aim of achieving gender balance, but maintaining the most scrupulous respect to any choice at the level of gender identity. Please express yourself freely, safely and non-binarily, if that's the case.

Deadline: Please submit your application by 09/09/2024

Data protection notice

In compliance with the obligations established in the General Regulation of Data Protection (RGPD), which is the Regulation (EU) 2016/679 of the Parliament and of the Council, of April 27, 2016, and the Organic Law 3/2018, of December 5, Protection of Personal Data and guarantee of digital rights, it is reported that the Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), CIF G58863317, with address Av. Granvia de l'Hospitalet, 199-203, 08908, L'Hospitalet de Llobregat, will process your personal data, as the controller, to apply for the position, maintain communication concerning the status of the candidature, to access the delivered CV; to compare that your data is in accordance with the offers announced by IDIBELL and to verify, where appropriate, that the information provided is accurate.

You can find more information in our Privacy Policy at https://idibell.cat/en/privacy-policy-2/, request more information about the data processing carried out and exercise your rights of access, rectification, deletion, opposition, portability, limitation of processing by sending a request at email: dataprotection@idibell.cat. If you consider that you have not obtained satisfaction in exercising your rights, you may submit a claim to Catalan Data Protection Authority.

Our institute

IDIBELL is a research center that integrates the biomedical research of the Bellvitge University Hospital (HUB), the Catalan Institute of Oncology (ICO), and the University of Barcelona in the Bellvitge Campus (UB), and the Viladecans Hospital (HV). The research focuses of IDIBELL are cancer, neuroscience, translational medicine and regenerative medicine. Research, innovation and society are the pivots on which researchers work every day in order to improve the quality of life of citizens.

Observations

The 'HR Excellence in Research' award represents IDIBELL’s commitment to the implementation of Human Resources policies, which oversee the attracting and development of talent in an open, transparent, and based on personal merit, in alignment with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment Researchers (Charter and Code).

IDIBELL is committed to the principles of the Code of Conduct for the Recruitment of Researchers of the European Commission and the implementation of open, transparent and merit-based recruitment (OTMR).