Postdoctoral researcher - Hematopoiesis and Leukemia

REF: 25-045_R_AG

About the research group

Identification of Molecular and Cellular Pathways involved in hematopoietic stem cell specification and oncogenic transformation

Hematopoiesis is a hierarchical process controlled by a rare population of multipotent hematopoietic stem cells (HSCs). Inherited disorders affecting HSCs and their progeny are responsible for malignant and non-malignant hematological diseases. The goal of studying hematopoietic development is not only to elucidate the development trajectory of blood cells, but also to provide insights for treatment of hematological disorders.

About the role

The candidate will be involved in the study named "Studying the Role of Bone Marrow Niche in GATA2 Deficiency (BMN-G2D) ", funded by MINECO. The project aims to investigate the contribution of affected bone marrow microenvironment on GATA2 deficiency progression. We employ a variety of methodologies to support our research, induced pluripotent stem cells culture and differentiation, 3D bone marrow organoids, CRISPR/Cas9-based genome engineering, and single cell transcriptomics, among others. Studying how GATA2 mutations affect the microenvironment and how the microenvironment contributes to malignant transformation can help us to design better treatment strategies and better transplants outcome.

Job requirements

Education and training

• B.Sc. in Life Sciences (Medicine, Pharmacy, Biology, Biotechnology, etc.)
  
  
• PhD Degree
  
  
• Animal certificate: FELASA D or equivalent 

Technical & soft skills

• Experience in cell biology (pluripotent, hematopoietic stem cells, mesenchymal stem cells. Endothelial cells).
  
  
• Experience in molecular techniques: DNA/RNA purification, vector cloning, PCR
  
  
• Molecular biology and extensive molecular cloning
  
  
• Flow cytometry (sorter and analysis)
  
  
• CRISPR/Cas9 editing
  
  
• RNAseq/ATACseq analysis
  
  
• scRNAseq
  
  
• Xenograft mouse models (IMBT, IV, Intra-Liver)
  
  
• Initiative, good capacity for planning and organizing the work schedule and a good predisposition to work in a multidisciplinary way with the rest of the professionals in the team
  
  
• Analytical and critical thinking
  
  
• Good communication skills and motivation to achieve project objectives. Skills in written and oral communication

Languages

• Good command of the English language

We will value, but not required

• Experience in basic computer tools (Excel, Access, Word,...)
  
  
• Capability of working independently and in a team
  
  
• Analytical skills and critical thinking

What do we offer

• No. of positions: 1
• Estimated start date: 22/04/2025
• Contract duration: Permanent linked to projects
• Estimated annual gross salary: 32.000 €
• You will be part of a multicultural team. We have a fun loving and friendly international work environment.
• Flexible working schedule - We know you have a life outside of work and we will work with you to make sure it's kept that way.
• Possibility to work some days in remote -Teleworking
• 26 working days of holiday per year
• System of accumulated hours for employees, from 88 to 104 hours depending on the year (11 to 13 working days), to attend to personal matters.
• Paid leave package
• Benefits of constant training are offered
• We offer and promote diverse and inclusive conditions. Applicants are made free from any discrimination. Specifically IDIBELL works to improve gender equality in all areas with the aim of achieving gender balance, but maintaining the most scrupulous respect to any choice at the level of gender identity. Please express yourself freely, safely and non-binarily, if that's the case.

Deadline: Please submit your application by  27/03/2025

Data protection notice

In compliance with the obligations established in the General Regulation of Data Protection (RGPD), which is the Regulation (EU) 2016/679 of the Parliament and of the Council, of April 27, 2016, and the Organic Law 3/2018, of December 5, Protection of Personal Data and guarantee of digital rights, it is reported that the Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), CIF G58863317, with address Av. Granvia de l'Hospitalet, 199-203, 08908, L'Hospitalet de Llobregat, will process your personal data, as the controller, to apply for the position, maintain communication concerning the status of the candidature, to access the delivered CV; to compare that your data is in accordance with the offers announced by IDIBELL and to verify, where appropriate, that the information provided is accurate. You can find more information in our Privacy Policy at https://idibell.cat/en/privacy-policy-2/, request more information about the data processing carried out and exercise your rights of access, rectification, deletion, opposition, portability, limitation of processing by sending a request at email: dataprotection@idibell.cat. If you consider that you have not obtained satisfaction in exercising your rights, you may submit a claim to Catalan Data Protection Authority.

Our institute

IDIBELL is a research center that integrates the biomedical research of the Bellvitge University Hospital (HUB), the Catalan Institute of Oncology (ICO), and the University of Barcelona in the Bellvitge Campus (UB), and the Viladecans Hospital (HV). The research focuses of IDIBELL are cancer, neuroscience, translational medicine and regenerative medicine. Research, innovation and society are the pivots on which researchers work every day in order to improve the quality of life of citizens.

Observations:

The 'HR Excellence in Research' award represents IDIBELL’s commitment to the implementation of Human Resources policies, which oversee the attracting and development of talent in an open, transparent, and based on personal merit, in alignment with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment Researchers (Charter and Code).

IDIBELL is committed to the principles of the Code of Conduct for the Recruitment of Researchers of the European Commission and the implementation of open, transparent and merit-based recruitment (OTMR).ç

The project leading to this labour contract has received funding from MINECO under the project code PID2023-146290OB-I00.